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Increasing prevalenceof the metabolic syndrome among U.S. These variants are grouped according to in-frame versus out-of-frame statusand their potential (or ability) to be translated into isoform proteins.

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At that time, however, it was assumed these effects weremediated by Mdm2 repression of p53, as loss of p53 can also promote genomeinstability [ 8 , 11 , 31].

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